Title: Alteration of Warfarins Pharmacologic Properties in Clathrates with Glycyrrhizic Acid and Arabinogalactan
Volume: 8
Issue: 3
Author(s): Tatjana G. Tolstikov, Mikhail V. Khvostov, Galina I. Lifshits, Alexander V. Dushkin and Elezaveta S. Meteleva
Affiliation:
Keywords:
Arabinogalactan, Clathration, Glycyrrhizic acid, Warfarin
Abstract: The article describes the pharmacological examinations of clathrates of warfarin (WF) with glycyrrhizic acid (GA) and arabinogalactan (AG). A direct connection between the clathrate structure and the pharmacons anticoagulative properties was observed. A 20 mg/kg (WF 2 mg/kg) dose of WF: GA 1:10 clathrate causes the increase in prothrombin time (PT) only in 54 hours, after 3 administrations. In contrast, a 20 mg/kg (WF 2 mg/kg) dose of WF: AG 1:10 clathrate leads to an increase in PT in 24 and 48 hours after a single administration, which corresponds to the effect of a comparator agent WF (2 mg/kg).