Title: Antimycobacterial Profile of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone Derivatives
Volume: 7
Issue: 8
Author(s): Samir A. Carvalho, Edson F. da Silva, Maria C.S. Lourenco, Marcus V.N. de Souza and Carlos A.M. Fraga
Affiliation:
Keywords:
1,3,4-thiadiazoles, Antimycobacterial activity, N-arylhydrazones, Tuberculosis
Abstract: In this work we report the tuberculostatic profile of a series of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone derivatives (1a-m). The evaluation of their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv was expressed as the minimum inhibitory concentration (MIC) in μg/mL. The compounds 1g and 1h exhibited inhibitory activity of 6.25 μg/mL and 1.25 μg/mL respectively, and can be considered as a good start point for the discovery of new lead compounds in the field of multi-drug resistant tuberculosis.
