Abstract
In this work we report the tuberculostatic profile of a series of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone derivatives (1a-m). The evaluation of their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv was expressed as the minimum inhibitory concentration (MIC) in μg/mL. The compounds 1g and 1h exhibited inhibitory activity of 6.25 μg/mL and 1.25 μg/mL respectively, and can be considered as a good start point for the discovery of new lead compounds in the field of multi-drug resistant tuberculosis.
Keywords: 1,3,4-thiadiazoles, Antimycobacterial activity, N-arylhydrazones, Tuberculosis
Letters in Drug Design & Discovery
Title: Antimycobacterial Profile of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone Derivatives
Volume: 7 Issue: 8
Author(s): Samir A. Carvalho, Edson F. da Silva, Maria C.S. Lourenco, Marcus V.N. de Souza and Carlos A.M. Fraga
Affiliation:
Keywords: 1,3,4-thiadiazoles, Antimycobacterial activity, N-arylhydrazones, Tuberculosis
Abstract: In this work we report the tuberculostatic profile of a series of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone derivatives (1a-m). The evaluation of their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv was expressed as the minimum inhibitory concentration (MIC) in μg/mL. The compounds 1g and 1h exhibited inhibitory activity of 6.25 μg/mL and 1.25 μg/mL respectively, and can be considered as a good start point for the discovery of new lead compounds in the field of multi-drug resistant tuberculosis.
Export Options
About this article
Cite this article as:
A. Carvalho Samir, F. da Silva Edson, C.S. Lourenco Maria, V.N. de Souza Marcus and A.M. Fraga Carlos, Antimycobacterial Profile of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone Derivatives, Letters in Drug Design & Discovery 2010; 7 (8) . https://dx.doi.org/10.2174/157018010792062768
DOI https://dx.doi.org/10.2174/157018010792062768 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
TNF-α and Ghrelin: Opposite Effects on Immune System, Metabolism and Mental Health
Protein & Peptide Letters Clinical Pharmacogenetics and Potential Application in Personalized Medicine
Current Drug Metabolism Mitochondria-Mediated Oxidative Stress: Old Target for New Drugs
Current Medicinal Chemistry Substituted Benzamides from Anti-inflammatory and p38 Kinase Inhibitors to Antitubercular Activity: Design, Synthesis and Screening
Mini-Reviews in Medicinal Chemistry Tumor Necrosis Alpha (TNF-α) Antagonists Used in Chronic Inflammatory Rheumatic Diseases: Risks and their Minimization Measures
Current Drug Safety Regulation of Adaptive Immunity by the Neurotransmitter Norepinephrine
Current Immunology Reviews (Discontinued) Modeling Anti-Allergic Natural Compounds by Molecular Topology
Combinatorial Chemistry & High Throughput Screening Tailored Multi-Target Agents. Applications and Design Considerations
Current Pharmaceutical Design Antibiotics in Malaria Therapy and their Effect on the Parasite Apicoplast
Current Molecular Medicine Failing a First Anti-TNF in RA: Does it Imply a Change in Target?
Current Rheumatology Reviews Protective Immunity in Humans: A Glimpse Provided by the Analysis of Herpesvirus-Specific T Cells in Health and Disease
Current Immunology Reviews (Discontinued) Editorial (Thematic Issue: Tropical Rheumatology)
Current Rheumatology Reviews Processed Foods, Dysbiosis, Systemic Inflammation, and Poor Health
Current Nutrition & Food Science Targeting Folate Metabolism in the Human Malaria Parasite Plasmodium falciparum
Current Enzyme Inhibition Inhibition Studies on Enzymes Involved in Isoprenoid Biosynthesis. Focus on Two Potential Drug Targets: DXR and IDI-2 Enzymes
Current Enzyme Inhibition Leptin as a Novel Therapeutic Target for Immune Intervention
Current Drug Targets - Inflammation & Allergy Uncommon Location for a Common Disease, Simulating Cervical Cancer: A Rare Case Report
Infectious Disorders - Drug Targets Phosphine-Gold(I) Compounds as Anticancer Agents: General Description and Mechanisms of Action
Anti-Cancer Agents in Medicinal Chemistry High Throughput Crystallography of TB Drug Targets
Infectious Disorders - Drug Targets Genetic Variants of Drug Metabolizing Enzymes and Drug Transporter (ABCB1) as Possible Biomarkers for Adverse Drug Reactions in an HIV/AIDS Cohort in Zimbabwe
Current HIV Research