Labeling of Oligopeptides with Luminescent Lanthanide(III) Chelates on Solid Phase

Title: Labeling of Oligopeptides with Luminescent Lanthanide(III) Chelates on Solid Phase

Volume: 6 Issue: 8

Author(s): Jari Peuralahti, Lassi Jaakkola, Harri Hakala, Veli-Matti Mukkala and Jari Hovinen

Affiliation:

Keywords: Lanthanide(III) chelates, oligopeptides, solid phase synthesis, labeling

Abstract: Synthesis of a building block based on 6,6-(1H-pyrazole-1,3-diyl)bis(pyridine) (3) that allows introduction of photoluminescent lanthanide(III) chelates to the synthetic oligopeptides on solid phase using the standard Fmoc chemistry is described. Since the ligand based on (3) forms luminescent chelates with Eu3+, Sm3+, Tb3+ and Dy3+ ions, the ligand is highly useful for multiparametric homogenous assays simplifying considerably the preparation of chelates needed in these applications.

Cite this article as:

Peuralahti Jari, Jaakkola Lassi, Hakala Harri, Mukkala Veli-Matti and Hovinen Jari, Labeling of Oligopeptides with Luminescent Lanthanide(III) Chelates on Solid Phase, Letters in Organic Chemistry 2009; 6 (8) . https://dx.doi.org/10.2174/157017809790442998