Title: Novel Synthesis of 3-Arylated 5,6-Dimethoxybenzo[d]isothiazole 1,1- Dioxides
Volume: 7
Issue: 4
Author(s): Fei Xie, Bing-Lei Gao, De-Feng Wang and Zhao-Peng Liu
Affiliation:
Keywords:
Ketimines, TMSCl/NaI/MeCN, cyclization, benzo[d]isothiazoles, sulfonamides
Abstract: A novel simple three-step synthesis of 3-arylated 5,6-dimethoxybenzo[d]isothiazole 1,1-dioxide is reported. ortho-Lithiation of N-tert-butyl-3,4-dimethoxybenzenesulfonamide followed by reaction with aryl aldehydes gave carbinol sulfonamides, which were oxidized into ketosulfonamides and converted to the ketimines via TMSCl/NaI/MeCN reagent mediated novel cyclization.
