Title: One-Pot Pictet-Spengler Reaction and Esterification for the Preparation of a Key Tadalafil Synthetic Intermediate
Volume: 7
Issue: 4
Author(s): Dina Scarpi, Ernesto G. Occhiato, Antonio Guarna and Valerio Borzatta
Affiliation:
Keywords:
Pictet-Spengler, esterification, isomerization, Tadalafil
Abstract: A new method is reported for the preparation of 2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester, a key intermediate in the synthesis of Tadalafil which is used for the treatment of male erectile dysfunction, via one-pot esterification and Pictet-Spengler reaction.
