Title: New Solid-Phase Approach to Synthesize a Hyacinthacine Core Using the L-Proline as a Building Block
Volume: 6
Issue: 1
Author(s): Monica O. Duarte, Guilherme Stedele, Mariane Pazinatto, Eduardo R. de Oliveira and Vera L. Eifler-Lima
Affiliation:
Keywords:
Hyacinthacine core, solid-phase organic synthesis, L-Proline, enaminoester, Baylis-Hillman reaction
Abstract: A new solid-phase synthesis of pyrrolizidine nucleus related to hyacinthacine core using L-proline as the starting material is reported. The final step is a new approach with a cyclization-cleave strategy, which releases the product from the resin in good yields under Baylis-Hillman conditions.