Title: The Stereoselective Total Synthesis of (1S,1R,5R,7R)-1-hydroxy-exo- Brevicomin by a Chiron Approach
Volume: 6
Issue: 1
Author(s): Jhillu S. Yadav, Kodepelly Sanjeeva Rao and Basi V. Subba Reddy
Affiliation:
Keywords:
D-glucono-δ-lactone, grignard cross coupling, wacker oxidation, acetalization, exo-brevicomin
Abstract: (1S,1R,5R,7R)-1-Hydroxy-exo-brevicomin has been synthesized in a highly efficient manner using Dglucono- δ-lactone as a chiral precursor. The synthesis involves the Grignard cross coupling, Wacker oxidation and intramolecular acetalization as the key steps.