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Reviews on Recent Clinical Trials

Editor-in-Chief

ISSN (Print): 1574-8871
ISSN (Online): 1876-1038

Immunotherapy of HCC

Author(s): Tim F. Greten, Michael P. Manns and Firouzeh Korangy

Volume 3, Issue 1, 2008

Page: [31 - 39] Pages: 9

DOI: 10.2174/157488708783330549

Price: $65

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Abstract

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide with increasing incidence in the Western World. In contrast to most other malignancies, only surgical and local ablative therapeutic options have shown efficacy in patients with HCC. Systemic chemotherapy has failed to show a substantial benefit for these patients. Therefore, a number of immunotherapeutic trials have been performed to evaluate the efficacy of immunotherapy for the treatment of HCC. Although only a limited number of patients have been enrolled in most trials so far, results from these studies clearly suggest that immunotherapy is safe in HCC patients. Here, we review recent immunotherapy trials in HCC.

Keywords: Radiofrequency thermo ablation, Transarterial chemoembolization, cytotoxic T lymphocytes, Interferon, Dendritic Cell


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