Abstract
Defects in mitochondrial function cause serious pediatric morbidity and mortality. Most mitochondrial disorders are caused by nuclear gene defects. To overcome the limitations of viral vectors for delivering gene products to mitochondria, we used protein transfection domains that cross cell membranes to deliver proteins expressed by nuclear genes to mitochondria.
Keywords: fatty acids, oxidation, ptd, tat, fusion proteins, mitochondria
Letters in Drug Design & Discovery
Title: Novel Therapeutic Approaches to Mitochondrial Disease
Volume: 1 Issue: 4
Author(s): J. A. Ibdah and R. M. Payne
Affiliation:
Keywords: fatty acids, oxidation, ptd, tat, fusion proteins, mitochondria
Abstract: Defects in mitochondrial function cause serious pediatric morbidity and mortality. Most mitochondrial disorders are caused by nuclear gene defects. To overcome the limitations of viral vectors for delivering gene products to mitochondria, we used protein transfection domains that cross cell membranes to deliver proteins expressed by nuclear genes to mitochondria.
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Cite this article as:
Ibdah A. J. and Payne M. R., Novel Therapeutic Approaches to Mitochondrial Disease, Letters in Drug Design & Discovery 2004; 1 (4) . https://dx.doi.org/10.2174/1570180043398506
DOI https://dx.doi.org/10.2174/1570180043398506 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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