Title: Advanced Pharmacophore Model of Non-Competitive AMPA Antagonist 2,3-benzodiazepines
Volume: 1
Issue: 3
Author(s): B. Rezessy and S. Solyom
Affiliation:
Keywords:
non-competitive ampa antagonist,, 2,3-benzodiazepines, pharmacophore model, disco
Abstract: Detailed SAR examination and DIStance COmparison (DISCO) computation were used for identification and superposition of common structural features of 2,3-benzodiazepines with high affinity to an allosteric AMPA binding site. Two similar 4-point models were identified; both contained 2 donor sites, a donor atom and a hydrophobic centre. At one of the donor sites a characteristic difference between the two models was observed.
