Title: Synthesis and in Vitro Anti-Proliferative Activity of Racemic Trifluoro-Casodex® (Bicalutamide)
Volume: 2
Issue: 5
Author(s): M. Sani, F. Viani, M. Binda, N. Zaffaroni and M. Zanda
Affiliation:
Keywords:
prostate cancer, anti-androgen, trifluoro-casodex analogue, nucleophilic reagents, chromatography
Abstract: The trifluoro analogue 1 of Casodex® was synthesized in racemic form, according to a strategy based on the use of trifluoropyruvate as a key starting material. This compound showed significant in vitro antiproliferative activity on the human prostate cancer cell line LNCaP.