Organic Synthesis in Solid Media. Alumina Supported Sodium Hydrogen Sulfate as an Effective and Reusable Catalyst for One-Pot Synthesis of Amides from Ketones in Dry Media Under Microwave Irradiation

Title: Organic Synthesis in Solid Media. Alumina Supported Sodium Hydrogen Sulfate as an Effective and Reusable Catalyst for One-Pot Synthesis of Amides from Ketones in Dry Media Under Microwave Irradiation

Volume: 2 Issue: 5

Author(s): M. Gopalakrishnan, P. Sureshkumar, V. Kanagarajan and J. Thanusu

Affiliation:

Keywords: alumina supported sodium hydrogen sulfate, amides, green chemistry

Abstract: A great variety of amides were effectively isolated in high yields from the reaction of ketones and hydroxylamine hydrochloride in the presence of alumina supported sodium hydrogen sulfate catalyst in dry media under microwave irradiation in solvent-free conditions. The major products were formed by the migration of the aryl group of the intermediate ketoximes during Beckmann rearrangement. The catalyst can be reused up to six times after simple washing with diethyl ether.

Cite this article as:

Gopalakrishnan M., Sureshkumar P., Kanagarajan V. and Thanusu J., Organic Synthesis in Solid Media. Alumina Supported Sodium Hydrogen Sulfate as an Effective and Reusable Catalyst for One-Pot Synthesis of Amides from Ketones in Dry Media Under Microwave Irradiation, Letters in Organic Chemistry 2005; 2 (5) . https://dx.doi.org/10.2174/1570178054405904