Title: Short Synthesis of the Selective Rho-Kinase Inhibitor Y-27632 and of Its Enantiomer
Volume: 2
Issue: 7
Author(s): D. Belotti, J. L. Peglion and J. Cossy
Affiliation:
Keywords:
kinase inhibitor, rho-associated kinase, reductive amination
Abstract: Y-27632 and its enantiomer were synthesized in 8 steps from trans-1,4-cyclohexanedicarboxylic acid by using a diastereoselective reductive amination of a ketone.
