Abstract
The synthesis of some steroidal dioximes (22-29) and their in vitro antineoplastic activity are described in this report. The oximino functionality was incorporated at position 3 and 17 of the 16- benzylidene substituted steroidal nucleus to study the importance of dioximino moiety on anticancer activity. The synthesized compounds were screened for their in vitro antitumor activity against the cell panel consisting of three lines (breast, brain and lungs) at NCI, Bethesda, USA. After selective analysis, compounds 23-28 indicated statistically significant antineoplastic activity for further studies.
Keywords: Steroidal, oxime, anticancer, dehydroepiandrosterone
Letters in Drug Design & Discovery
Title: Synthesis and Evaluation of Some 16-Benzylidene Substituted 3,17- Dioximino Androstene Derivatives as Anticancer Agents
Volume: 2 Issue: 7
Author(s): Sonal Dubey, Poonam Piplani and Dharam P. Jindal
Affiliation:
Keywords: Steroidal, oxime, anticancer, dehydroepiandrosterone
Abstract: The synthesis of some steroidal dioximes (22-29) and their in vitro antineoplastic activity are described in this report. The oximino functionality was incorporated at position 3 and 17 of the 16- benzylidene substituted steroidal nucleus to study the importance of dioximino moiety on anticancer activity. The synthesized compounds were screened for their in vitro antitumor activity against the cell panel consisting of three lines (breast, brain and lungs) at NCI, Bethesda, USA. After selective analysis, compounds 23-28 indicated statistically significant antineoplastic activity for further studies.
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Cite this article as:
Dubey Sonal, Piplani Poonam and Jindal P. Dharam, Synthesis and Evaluation of Some 16-Benzylidene Substituted 3,17- Dioximino Androstene Derivatives as Anticancer Agents, Letters in Drug Design & Discovery 2005; 2 (7) . https://dx.doi.org/10.2174/157018005774479186
DOI https://dx.doi.org/10.2174/157018005774479186 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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