Title: Novel Naproxen Derivatives: Lewis Acid/Transition-metal Free Synthesis via C-C Bond Forming Reaction
Volume: 4
Issue: 4
Author(s): Sarbani Pal, P. Bindu, Pragnyadhar Reddy Venna and P. K. Dubey
Affiliation:
Keywords:
Naproxen, acylation, trifluoroacetic anhydride, phosphoric acid
Abstract: Naproxen or 2-(6-methoxy naphthalen-2-yl)propionic acid participated in trifluoroacetic anhydride/ phosphoric acid mediated C-C bond forming reaction in a regioselective fashion when treated with a variety of arene or heteroarene under a solvent-free condition affording novel 1-aryl/heteroaryl substituted 2-(6-methoxy naphthalen-2-yl)propan-1-ones in good yields.
