Title: Synthesis of Gallocatechin-3-Gallate Analogues
Volume: 4
Issue: 4
Author(s): Nadia Vaiana, Luca Rizzi, Maria G. Pezzano, Roberto Restelli, Filippo Rota, Silvia Stefanini, Silvia Vicentini and Sergio Romeo
Affiliation:
Keywords:
Gallocatechin, catechins, total synthesis, structure-reactivity study, EGCG
Abstract: The influence of substituents on the yields of the synthesis of seven catechines analogues has been studied. 3-Flavene formation is favoured by electron donors substituents on the A and B rings. Yields of the hydroboration reaction are increased by electron donor substituents on the A ring, while substituents on the B ring do not affect the reaction outcome.
