Title: Nanoclay-Catalyzed Tandem Conjugate Addition-Annulation Protocol for Imidazo-1,3-Thiazines
Volume: 4
Issue: 3
Author(s): Lal Dhar Singh Yadav and Ritu Kapoor
Affiliation:
Keywords:
Nanoclay-catalyzed, solvent-free, chalcones, cyclic thioureas, microwaves, imidazo-1,3-thiazines
Abstract: A nanoclay-catalyzed atom and energy-efficient low hazardous tandem conjugate additioncyclodehydration of cyclic thioureas (ethylenethiourea and 2-mercaptoimidazole/-benzimidazole) with dielectrophiles (chalcones) readily annulates a 1,3-thiazine ring on imidazoles to yield 7H-imidazo[2,1-b]-1,3- thiazines under solvent-free microwave irradiation in a one-pot procedure.
