Title: New Synthesis of 3-Aryl Isoquinolines by Pd-Catalyzed Suzuki Cross-Coupling
Volume: 4
Issue: 2
Author(s): Marco Franceschin, Stefano Frasca, Antonello Alvino and Armandodoriano Bianco
Affiliation:
Keywords:
Suzuki cross-coupling, Pd catalysis, 3-aryl isoquinolines
Abstract: A new synthetic approach to 3-aryl isoquinolines, based on the Pd-catalyzed Suzuki cross-coupling reaction, is reported. The described procedure represents an efficient method to prepare 3-aryl isoquinolines by reaction of a preformed 3-chloro isoquinoline with a phenylboronic acid, especially when the nitrogen atom is positively charged.