Title: The Role of T and B Cells in Atherosclerosis: Potential Clinical Implications
Volume: 17
Issue: 37
Author(s): I. E. Dumitriu and J. C. Kaski
Affiliation:
Keywords:
Adaptive immune response, T cells, B cells, atherosclerosis, metallo-proteinases (MMPs), acute coronary syndrome (ACS), macrophages, monoclonal antibody, rheumatoid arthritis, systemic lupus erythematosus
Abstract: The chronic inflammation process that characterises atherosclerosis involves both the innate and adaptive arms of the immune system. Several lines of evidence have recently highlighted pivotal roles for T and B lymphocytes – cells that belong to the adaptive immune system – in the development and progression of atherosclerosis. In this review, we summarise the current knowledge on the roles of adaptive immune responses in atherosclerosis and present our views on how a better understanding of these immune mechanisms could shape future therapies to slow down or even prevent this disease.
