Title: Histamine H3 Receptor (H3R) Antagonists and Inverse Agonists in the Treatment of Sleep Disorders
Volume: 17
Issue: 15
Author(s): Meredith Broderick and Tony Masri
Affiliation:
Keywords:
Histamine, H3 receptor, H3R antagonists, histamine H3 receptor H3R inverse agonists, narcolepsy treatment, excessive daytime sleepiness, antihistamine, sleepiness, narcolepsy, metabotropic, tuberomammillary, diurnal, orexin, preoptic, accumbens, globus pallidus, substantia nigra, presynaptically, norepinephrine, thioperamide
Abstract: After the discovery and characterization of the H3R and H4R receptors, they have become widely anticipated as potential therapeutic agents in the treatment of sleep disorders. In preliminary studies, histamine H3 receptor (H3R) antagonists and inverse agonists have demonstrated promise in the treatment of sleep disorders associated with excessive daytime sleepiness. This review article summarizes the current research in this area and characteristics of H3R and H3R antagonists and inverse agonists in development.
