Title:Advancements in Pyrazine Derivatives as Anticancer Agents: A Comprehensive Review (2010-2024)
Volume: 25
Issue: 3
Author(s): Mohammed Merae Alshahrani*
Affiliation:
- Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, 1988, Najran, 61441, Saudi
Arabia
Keywords:
Cancer, therapeutic strategies, pyrazine, heterocyclic compounds, aromatic ring, anticancer agents.
Abstract: Cancer, an intricate and formidable disease, continues to challenge Medical Science with its diverse
manifestations and relentless progression. In the pursuit of novel therapeutic strategies, organic heterocyclic compounds
have emerged as promising candidates due to their versatile chemical structures and intricate interactions
with biological systems. Among these, pyrazine derivatives are characterized by a six-membered aromatic ring
containing four carbon and two nitrogen atoms situated in a 1,4-orientation. These compounds garnered significant
attention for their potential as anticancer agents. This comprehensive review provides a detailed analysis of
the advancements made during this timeframe, encompassing the chemical diversity of pyrazine derivatives, their
mechanisms of action at the cellular level, and structure-activity relationships, spanning the years 2010 to 2024.
By examining their therapeutic potential, challenges, and future prospects, this review offers valuable insights
into the evolving landscape of pyrazine derivatives as potent tools in the fight against cancer.
