Microwave-assisted Synthesis and Reactivity of Some Novel Chromenopyridine Derivatives Bearing 2,4-Diamino-3-Carbonitrile Moieties

Title:Microwave-assisted Synthesis and Reactivity of Some Novel Chromenopyridine Derivatives Bearing 2,4-Diamino-3-Carbonitrile Moieties

Volume: 22 Issue: 3

Author(s): Amira Trabelsi, Emna khdhiri*, Souhir Abid, Lujain M. Althobaiti and Houcine Ammar

Affiliation:

• Laboratoire de Chimie Appliquée 'Hétérocycles Corps Gras & Polymères', Faculté des Sciences, Université de Sfax, 3038 Sfax, Tunisia

Keywords: Chromenopyridine derivatives, triethyl orthoformate, microwave irradiation, chromenopyridine formimidate, 1D NMR, elemental analysis.

Abstract: In the current study, we reported a cost-effective, simple strategy for the synthesis and reactivity of a novel series of chromenopyridine derivatives involving 2,4-diamino-3-carbonitrile moieties. These new compounds were synthesized in good yields from malononitrile and various chromene derivatives as a precursor, which was prepared by the reduction of iminocoumarin derivatives. The formed iminocoumarin was obtained by Knoevenagel condensation from malononitrile and different aromatic aldehydes. These novel chromenopyridine derivatives were further reacted with triethyl orthoformate under microwave irradiation to afford the final compounds, namely "chromenopyridine formimidate." The structures of all molecules were characterized by FT-IR, ¹H NMR, ¹³C NMR, and elemental analysis.

Cite this article as:

Trabelsi Amira, khdhiri Emna*, Abid Souhir, Althobaiti M. Lujain and Ammar Houcine, Microwave-assisted Synthesis and Reactivity of Some Novel Chromenopyridine Derivatives Bearing 2,4-Diamino-3-Carbonitrile Moieties, Letters in Organic Chemistry 2025; 22 (3) . https://dx.doi.org/10.2174/0115701786316461240801065332