Title:Targeting the Receptor Complexes by Structure-based Natural Drug Compounds in Seizures: A New Dimension in Drug Discovery and Design
Volume: 15
Issue: 4
Author(s): Elahe Aleebrahim-Dehkordi*, Ali Jafari, Auwal Adam Bala, Ahmadreza Lagzian, Hamed Ghoshouni, Pooneh Koochaki, Neda Faal Hamedanchi, Sayedeh Zohreh Azadeh-Ghahfaroghi, Fariba Azadikhah, Nafiseh Taei, Sahar Valizadeh, Shirin Saberianpour and Hamidreza Zalpoor*
Affiliation:
- Systematic Review and Meta-Analysis Expert Group (SRMEG), Universal Scientific Education and Research Network
(USERN), Tehran, Iran
- Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of
Medical Sciences, Shahrekord, Iran
- Shiraz Neuroscience
Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
- Network of Immunity in Infection, Malignancy
and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Keywords:
Seizures, natural compounds, receptor proteins, molecular mechanisms, drug design, neurodegenerative, oxidative stress, medicinal plants.
Abstract: A seizure is the brain's uncontrolled, abnormal electrical activity, which may result in
altered states of consciousness, behavior, memory, or emotion. Seizures start biologically with the
activation of susceptible brain neurons, which causes synchronized discharges of larger groups of
connected neurons. A few potential causes of seizures include medications, genetics, electrolyte abnormalities,
sleep state, infections, brain inflammation, and injuries. Medicinal plants are a rich
source of various chemical molecules with distinct structures and biological activity. Most plants
contain active components, including coumarin, glycosides, alkaloids, terpenoids, flavonoids, peptidoglycans,
and other elements often associated with the effects of antiseizures. Isolating and identifying
biologically active compounds and molecules from nature have resulted in the development of
novel treatments, which in turn have contributed to the advancement of the health and pharmaceutical
sectors throughout the history of humanity. In this review, we thoroughly summarize the information
on the anti-seizure activities of medicinal plants and bioactive chemicals, focusing on molecular
targets and cellular signaling pathways. All available research has contributed to medicinal
plants as a reasonable option for seizure prevention and treatment, as well as drug development and
manufacturing. To better comprehend the underlying molecular mechanisms, more research is required.
If these mechanisms are discovered, it will be easier to identify new targets and create innovative
anti-seizure therapeutic drugs to enhance patient survival and life quality. This work is expected
to provide insights and ideas for the further research of Bioactive compounds from medicinal
plants, their qualities, and the scientific basis for their improved clinical use.
