Title:Research Progress in Natural Products against Liver Fibrosis
Volume: 15
Issue: 4
Author(s): Siyu Zhao, Xin Chen, Rui Tan, Xiaoqing Wu*Hezhong Jiang*
Affiliation:
- School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, P.R. China
- School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, P.R. China
Keywords:
Anti-liver fibrosis, natural products, cells, pathways, mechanisms, active pharmaceutical ingredients.
Abstract: Fibrosis of the liver is the most common pathological feature of many chronic liver diseases,
progressing to cirrhosis and eventually liver cancer. Currently, only individual genes or proteins
are targeted by synthetic drugs used to treat liver fibrosis, they have limited therapeutic effect,
and are associated with many side effects. In contrast, natural products have shown great advantages
and potential in the treatment of liver fibrosis due to their structural diversity, high multi-target activity
and low toxicity and side effects. Therefore, this review concludes the pathological mechanism of
liver fibrosis and the cellular and signaling pathways involved, provides new ideas for anti-liver fibrosis
research and introduces common natural products and their anti-hepatic fibrosis mechanisms.