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The Natural Products Journal

Editor-in-Chief

ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

Mini-Review Article

Research Progress in Natural Products against Liver Fibrosis

Author(s): Siyu Zhao, Xin Chen, Rui Tan, Xiaoqing Wu* and Hezhong Jiang*

Volume 15, Issue 4, 2025

Published on: 04 June, 2024

Article ID: e040624230657 Pages: 12

DOI: 10.2174/0122103155293866240522085229

Price: $65

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Abstract

Fibrosis of the liver is the most common pathological feature of many chronic liver diseases, progressing to cirrhosis and eventually liver cancer. Currently, only individual genes or proteins are targeted by synthetic drugs used to treat liver fibrosis, they have limited therapeutic effect, and are associated with many side effects. In contrast, natural products have shown great advantages and potential in the treatment of liver fibrosis due to their structural diversity, high multi-target activity and low toxicity and side effects. Therefore, this review concludes the pathological mechanism of liver fibrosis and the cellular and signaling pathways involved, provides new ideas for anti-liver fibrosis research and introduces common natural products and their anti-hepatic fibrosis mechanisms.

Keywords: Anti-liver fibrosis, natural products, cells, pathways, mechanisms, active pharmaceutical ingredients.


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