Title:Impact of Bioactive Compounds in the Management of Various Inflammatory
Diseases
Volume: 30
Issue: 24
Author(s): Ritchu Babbar*, Arpanpreet Kaur, Vanya, Rashmi Arora, Jeetendra Kumar Gupta, Pranay Wal, Arpan Kumar Tripathi, Akshada Amit Koparde, Pradeep Goyal, Seema Ramniwas, Monica Gulati and Tapan Behl*
Affiliation:
- Chitkara College of Pharmacy, Chitkara University, Punjab, India
- Amity School of Pharmaceutical Sciences, Amity University, Mohali, Punjab, India
Keywords:
Inflammation, bioactive compounds, plant-derived, marine-derived, anti-inflammatory action, inflammatory diseases.
Abstract: Inflammation is an individual’s physiological response to a sequence of physical, chemical, or infectious
stressors acting mainly to provide localized protection. Although inflammation is a protective and thus
beneficial process, its excess or prolonged action can be harmful to the body. An increasing number of the population
worldwide are changing their lifestyles, which leads to a rise in inflammatory diseases, such as atherosclerosis,
angina pectoris, myocardial infarction, ulcerative colitis, cancer, and many more. Their treatment is
based majorly on the pharmacological approach. However, natural products or bioactive compounds are of
great significance in inflammation therapy because they show minimum side effects and maximum bioavailability.
Therefore, it is critical to investigate bioactive substances that can modify target functions associated
with oxidative stress defense and might be used to achieve various health benefits. This review accentuates the
essence of bioactive chemicals used in the treatment of inflammation and other inflammatory illnesses. These
bioactive compounds can be of any origin, such as plants, animals, bacteria, fungi, marine invertebrates, etc.
Bioactive compounds derived from plant sources, such as glycyrrhizin, lignans, lycopene, resveratrol, indoles,
and phenolic and polyphenolic compounds, work mainly by reducing oxidative stress and thereby preventing
various inflammatory disorders. A large diversity of these anti-inflammatory bioactive compounds has also
been discovered in marine environments, giving rise to an increase in the interest of various scientists in
marine invertebrates and microbes. The vast diversity of microbes found in the marine environment represents
an enormous supply to extract novel compounds, such as from bacteria, cyanobacteria, fungi, algae, microalgae,
tiny invertebrates, etc. In the present review, an attempt has been made to summarize such novel bioactive
compounds that help prevent inflammatory responses via different mechanisms of action.
