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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

MicroRNAs as Key Regulators in RA and SLE: Insights into Biological Functions

Author(s): Xiao-Xiao Li, Chan-Na Zhao, Hai-Fen Wei, Sheng Li, Jian Tang, Yan-Yu Zhu, Xue-Er Cheng, Qian-Qian Shi, Peng Wang* and Hai-Feng Pan*

Volume 30, Issue 22, 2024

Published on: 24 May, 2024

Page: [1746 - 1761] Pages: 16

DOI: 10.2174/0113816128303695240512141729

Price: $65

Abstract

MicroRNAs (miRNAs) are non-coding RNA molecules that bind to mRNAs to regulate gene expression. Since changes in miRNA expression levels have been found in a variety of autoimmune illnesses, miRNAs are important in autoimmune diseases. MiRNAs serve not only as pathogenic factors and biomarkers for autoimmune diseases but also as important targets for disease therapeutics. Although miRNA-based treatments are still in the research stage, in-depth investigations into the biological functions of miRNAs have significantly enhanced our understanding of their mechanisms in autoimmune diseases. The purpose of this review is to summarize the biological functions of miRNAs, their roles in rheumatoid arthritis and systemic lupus erythematosus, therapeutic strategies, and challenges.

Keywords: MiRNA, rheumatoid arthritis, systemic lupus erythematosus, autoimmune disease, therapeutics, biomarker, DNA methylation.

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