Title:Advancing Novel Strategies against Post-surgical Tendon Adhesion Bands,
Exploring New Frontiers
Volume: 30
Issue: 21
Author(s): Maryam Alaei, Doaa Jawad-Kadhim Abdulhasan, Amirhossein Barjasteh, Abdulridha Mohammed Al-Asady, Hanieh Latifi, Ehsan Vahedi, Amir Avan, Majid Khazaei, Mikhail Ryzhikov and Seyed Mahdi Hassanian*
Affiliation:
- Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
- Metabolic Syndrome Research
Center, Mashhad University of Medical Sciences, Mashhad, Iran
Keywords:
Tendon, post-surgical adhesion band, adhesion therapy, spectrum, quality of life, anti-inflammation.
Abstract: Current interest in adhesion formation stems from its global impact on the function and quality of
life, spanning a spectrum of subtle impairments to significant disabilities, based on the affected area and the extent
of adhesion. Yet therapeutic agents are restricted to prophylactic anti-inflammatories, revision surgeries,
and biological and physical techniques, none of which grant a decent outcome. Recent advancements in tissue-
engineered biomaterials, drug delivery systems, and fabricating technologies such as nanoparticles, hydrogels,
and weaving or braiding demonstrate potential for improved outcomes. However, none of the mentioned
methods have reliable outcomes, thus this study aims to elucidate the mechanisms involved in the pathophysiology
of tendon adhesion and post-surgical adhesion band formation (PSAB), with a closer look at inflammatory
pathways stimulating the process. This article consolidates information on diverse therapeutic and prophylactic
methods and cutting-edge technologies, aiming to provide a comprehensive update on this topic, and providing
researchers an avenue for new and innovative ideas for further investigations.
