Title:The Therapeutic Application of Hydrogen in Cancer: The Potential and
Challenges
Volume: 30
Issue: 17
Author(s): Morteza Nazari Khiji, Faezeh Arghidash, Ghazaleh Khalili Tanha, Rasoul Hossein Zadeh, Elnaz Ghorbani, Majid Khazaei, Seyed Mahdi Hassanian, Ibrahim Saeed Gataa, Alfred King-Yin Lam, Elisa Giovannetti, Gordon A. Ferns, Elham Nazari*Amir Avan*
Affiliation:
- Department of Health Information,
Technology and Management, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
- Metabolic Syndrome Research
Center, Mashhad University of Medical Sciences, Mashhad, Iran
- Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia
Keywords:
Hydrogen, cancer, oxidative stress, therapeutic application, antioxidant, inflammation.
Abstract: Hydrogen therapy has emerged as a possible approach for both preventing and treating cancer. Cancers
are often associated with oxidative stress and chronic inflammation. Hydrogen, with its unique physiological
functions and characteristics, exhibits antioxidant, anti-inflammatory, and anti-apoptotic properties, making
it an attractive candidate for cancer treatment. Through its ability to mitigate oxidative damage, modulate
inflammatory responses, and sustain cellular viability, hydrogen demonstrates significant potential in preventing
cancer recurrence and improving treatment outcomes. Preclinical studies have shown the efficacy of hydrogen
therapy in several cancer types, highlighting its ability to enhance the effectiveness of conventional treatments
while reducing associated side effects. Furthermore, hydrogen therapy has been found to be safe and
well-tolerated in clinical settings. Nonetheless, additional investigations are necessary to improve a comprehensive
understanding of the mechanisms underlying hydrogen's therapeutic potential and refine the administration
and dosage protocols. However, further clinical trials are still needed to explore its safety profile and capacity.
In aggregate, hydrogen therapy represents an innovative and promising treatment for several malignancies.
