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Anti-Cancer Agents in Medicinal Chemistry

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ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

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Case Report

Primary Pulmonary Lymphoepithelioma-like Carcinoma: A Case Report Utilizing Camrelizumab and Anlotinib for Prolonged Survival

Author(s): ShuangYi Lei*, ShanShan Tian, SongMei Lu, Zhou Qing, JianLin Long, LuChun Li and Dan Yang*

Volume 24, Issue 12, 2024

Published on: 15 April, 2024

Page: [954 - 960] Pages: 7

DOI: 10.2174/0118715206294031240404071838

Price: $65

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Abstract

Background: Primary Pulmonary Lymphoepithelioma-like Carcinoma (PPLELC) is a rare form of cancer for which no standard treatment has been established to date. Patients with advanced-stage PPLELC generally have a poor prognosis with overall survival of 22.7 months.

Case Presentation: Here, we report a case of advanced primary pulmonary lymphoepithelioma-like carcinoma. Initially, the patient underwent a first-line (GP) and a second-line (DP) of chemotherapy, which provided temporary relief but resulted in varying degrees of myelosuppression. When the disease progressed again, we administered a third-line treatment consisting of camrelizumab combined with anlotinib.

Result: This resulted in a progression-free survival of over 26 months without significant toxic side effects.

Conclusion: Our findings suggest that combining camrelizumab and anlotinib could lead to a long progressionfree survival in patients with advanced PPLELC.

Keywords: Primary pulmonary lymphoepithelioma-like carcinoma, PD-1, camrelizumab, anlotinib, case report, chemotherapy.

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