Title:CASC19: An Oncogenic Long Non-coding RNA in Different Cancers
Volume: 30
Issue: 15
Author(s): Yinxin Wu, Jie Mou, Gang Zhou*Chengfu Yuan*
Affiliation:
- College of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China
- Yichang Hospital of Traditional Chinese Medicine, Yichang 443002, China
- Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang 443002, China
- College of Basic Medical Science, China Three Gorges University, Yichang 443002, China
- Third-grade Pharmacological Laboratory
on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University,
Yichang 443002, China
Keywords:
LncRNA, CASC19, tumors, biomarkers, radiation resistance, gastric cancer.
Abstract: A 324 bp lncRNA called CASC19 is found on chromosome 8q24.21. Recent research works have
revealed that CASC19 is involved in the prognosis of tumors and related to the regulation of the radiation tolerance
mechanisms during tumor radiotherapy (RT). This review sheds light on the changes and roles that
CASC19 plays in many tumors and diseases, such as nasopharyngeal carcinoma (NPC), cervical cancer, colorectal
cancer (CRC), non-small cell lung cancer (NSCLC), clear cell renal cell carcinoma (ccRCC), gastric
cancer (GC), pancreatic cancer (PC), hepatocellular carcinoma (HCC), glioma, and osteoarthritis (OA).
CASC19 provides a new strategy for targeted therapy, and the regulatory networks of CASC19 expression levels
play a key role in the occurrence and development of tumors and diseases. In addition, the expression level
of CASC19 has predictive roles in the prognosis of some tumors and diseases, which has major implications
for clinical diagnoses and treatments. CASC19 is also unique in that it is a key gene affecting the efficacy of
RT in many tumors, and its expression level plays a decisive role in improving the success rate of treatments.
Further research is required to determine the precise process by which CASC19 causes changes in diseased
cells in some tumors and diseases.
