Abstract
Introduction: Phytochemical investigation on the twigs and leaves of Aglaia lawii (Wight) C. J. Saldanha led to the isolation and characterization of sixteen compounds, including five sesquiterpenoids (1-5), one terpenoidal macrolide (6), seven phenolic compounds (7-13), two triterpenoids (14-15), and one steroid (16).
Method: Their structures were identified by spectroscopic analyses and comparison with the literature data. Eight out of the sixteen compounds were discovered from the genus Aglaia for the first time.
Result: The sesquiterpenoids (1-5) may serve as important chemotaxonomic markers. In vitro, bioassays on the anti-inflammatory and anti-diabetic activities of compounds 1‒6 were accomplished.
Conclusion: Ozoroalide (6) could significantly inhibit LPS-stimulated NO production in RAW264.7 macrophages at 40 μM and caryolane-1,9β-diol (5) could largely increase the glucose uptake capacity of C2C12 cells under insulin stimulation.
Keywords: Aglaia lawii, terpenoids, chemotaxonomic markers, anti-inflammatory, anti-diabetic, insulin.
[http://dx.doi.org/10.1080/10286020903565226] [PMID: 20390768]
[http://dx.doi.org/10.1016/0040-4020(96)00322-5]
[http://dx.doi.org/10.1021/np970163+] [PMID: 9214732]
[http://dx.doi.org/10.1021/np060428x] [PMID: 17190457]
[http://dx.doi.org/10.1016/j.phytochem.2020.112540] [PMID: 33130371]
[http://dx.doi.org/10.1016/j.bse.2022.104427]
[http://dx.doi.org/10.1016/j.fitote.2022.105260] [PMID: 35931289]
[http://dx.doi.org/10.1016/j.phytochem.2012.01.015] [PMID: 22321385]
[http://dx.doi.org/10.1016/j.phytochem.2008.08.025] [PMID: 18930298]
[http://dx.doi.org/10.1016/j.phytol.2016.02.003]
[http://dx.doi.org/10.1016/S0031-9422(99)00053-9]
[http://dx.doi.org/10.1002/hlca.201500228]
[http://dx.doi.org/10.1016/j.phytochem.2020.112651] [PMID: 33418167]
[http://dx.doi.org/10.1016/S0031-9422(99)00519-1] [PMID: 10820837]
[http://dx.doi.org/10.18632/oncotarget.17287] [PMID: 29050217]
[http://dx.doi.org/10.1080/14786419.2021.1893723] [PMID: 33703953]
[http://dx.doi.org/10.2174/1385272013375049]
[http://dx.doi.org/10.1021/np070476x] [PMID: 18078326]
[http://dx.doi.org/10.1515/znc-2010-1-207] [PMID: 20355319]
[http://dx.doi.org/10.1016/S0031-9422(00)00463-5] [PMID: 11314967]
[http://dx.doi.org/10.3987/COM-00-9045]
[http://dx.doi.org/10.1021/np401089h] [PMID: 24621263]
[http://dx.doi.org/10.1021/acs.jnatprod.7b00347] [PMID: 28719204]
[http://dx.doi.org/10.1016/j.bioorg.2021.105030] [PMID: 34089946]
[http://dx.doi.org/10.1016/j.foodchem.2018.07.117] [PMID: 30174051]
[http://dx.doi.org/10.1007/s10600-006-0166-7]
[http://dx.doi.org/10.1080/14786419.2020.1739677] [PMID: 32189507]
[http://dx.doi.org/10.1016/S0031-9422(03)00294-2] [PMID: 12946429]
[http://dx.doi.org/10.1021/np200146x] [PMID: 21561060]
[http://dx.doi.org/10.1016/S0040-4020(01)89002-5]
[http://dx.doi.org/10.1016/j.fitote.2007.04.001] [PMID: 17553631]
[http://dx.doi.org/10.1007/s10600-012-0179-3]
[http://dx.doi.org/10.1021/np0206108] [PMID: 15043418]
[http://dx.doi.org/10.1007/s10600-018-2523-8]
[http://dx.doi.org/10.1021/acs.joc.8b02156] [PMID: 30372074]
[http://dx.doi.org/10.1248/cpb.51.62] [PMID: 12520130]
[http://dx.doi.org/10.1002/jccs.201500395]
[http://dx.doi.org/10.1016/S0031-9422(00)97581-2]
[http://dx.doi.org/10.1007/s10600-021-03520-w]
[http://dx.doi.org/10.20884/1.jm.2018.13.1.410]
[http://dx.doi.org/10.20884/1.jm.2019.14.2.543]
[http://dx.doi.org/10.22146/ijc.68383]
[http://dx.doi.org/10.1080/14786419.2022.2135001] [PMID: 36580570]
[http://dx.doi.org/10.1080/14786419.2014.924934] [PMID: 24934340]
[http://dx.doi.org/10.1080/14786419.2010.508038] [PMID: 22011221]
[http://dx.doi.org/10.1021/np9905923] [PMID: 10843575]
[http://dx.doi.org/10.1021/jo040120f] [PMID: 15132542]
[http://dx.doi.org/10.1021/np960346g] [PMID: 8759160]
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