The Emerging Role of Cell Membrane-coated Nanomaterials in Cancer
Therapy

Sankha      Bhattacharya; Paul      Beninger

doi:10.2174/0113816128295414240221063434

Abstract

This review investigates the revolutionary application of cell membrane-coated nanoparticles (CMNPs) as a promising avenue for cancer therapy within the embryonic landscape of nanotechnology. Nanoparticles, pivotal in cancer treatment, are systematically examined for their diverse physicochemical structures, categorized as organic (lipid-based, protein-based, and polymer-assisted) and inorganic (carbon-based and metal) varieties. A significant focus is placed on CMNPs, which serve as an innovative drug delivery vehicle, overcoming limitations associated with conventional nanoparticle therapies. This manuscript accurately explores the advantages and challenges of various cell membranes, including those derived from cancer cells, red blood cells, platelets, stem cells, and white blood cells. Importance is placed on their roles in enhancing drug delivery precision, immune system circumvention, and targeted recognition. Detailed insights into the crafting of CMNPs are provided, elucidating membrane extraction and fusion techniques, such as sonication, extrusion, co-extrusion, and microfluidic electroporation. Maintaining membrane integrity during extraction and the benefits of coating techniques in augmenting biocompatibility and targeted drug delivery are underscored. This comprehensive resource consolidates the latest advancements in targeted drug delivery, positioning itself at the forefront of nanotechnology and biomedicine research. Encapsulating various methodologies like membrane extrusion, electrospray, and chemical conjugation, this manuscript showcases the expanding toolbox available to researchers in this dynamic field. Focusing on the unique characteristics of CMNPs, this review explores their multifaceted applications in biomedical research, particularly in tumour therapy. It provides an indepth analysis of the biocompatibility of CMNPs, their stability, immune evasion capabilities, targeted drug delivery precision, increased payload capacity, and retained biological functionality. The manuscript outlines current applications and future prospects of CMNPs in targeted chemotherapy, photothermal and photodynamic therapy, immunotherapy, gene therapy, and innovative therapeutic methods. It concludes by highlighting the advantages of CMNPs in tumour therapy and their transformative potential in reshaping the landscape of cancer treatment.

Keywords: Cell membrane-coated nanoparticles, tumour therapy, drug delivery, biocompatibility, immune evasion, precision targeting.

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DOI https://dx.doi.org/10.2174/0113816128295414240221063434	Print ISSN 1381-6128
Publisher Name Bentham Science Publisher	Online ISSN 1873-4286

Current Pharmaceutical Design

The Emerging Role of Cell Membrane-coated Nanomaterials in Cancer Therapy

Abstract

Advances in the Molecular Pathogenesis of Inflammatory Bowel Disease.

Blood-based biomarkers in large-scale screening for neurodegenerative diseases

Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions

Diabetes mellitus: advances in diagnosis and treatment driving by precision medicine

Current Pharmaceutical Design

The Emerging Role of Cell Membrane-coated Nanomaterials in Cancer Therapy

Abstract

Call for Papers in Thematic Issues

Advances in the Molecular Pathogenesis of Inflammatory Bowel Disease.

Blood-based biomarkers in large-scale screening for neurodegenerative diseases

Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions

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