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Review Article

Cholesteryl Ester Transfer Protein (CETP) Variations in Relation to Lipid Profiles and Cardiovascular Diseases: An Update

Author(s): Siarhei Dabravolski*, Nikolay A. Orekhov, Alexandra Melnichenko, Vasily N. Sukhorukov, Mikhail A. Popov and Alexander Orekhov

Volume 30, Issue 10, 2024

Published on: 29 February, 2024

Page: [742 - 756] Pages: 15

DOI: 10.2174/0113816128284695240219093612

Price: $65

Abstract

Lipid metabolism plays an essential role in the pathogenesis of cardiovascular and metabolic diseases. Cholesteryl ester transfer protein (CETP) is a crucial glycoprotein involved in lipid metabolism by transferring cholesteryl esters (CE) and triglycerides (TG) between plasma lipoproteins. CETP activity results in reduced HDL-C and increased VLDL- and LDL-C concentrations, thus increasing the risk of cardiovascular and metabolic diseases. In this review, we discuss the structure of CETP and its mechanism of action. Furthermore, we focus on recent experiments on animal CETP-expressing models, deciphering the regulation and functions of CETP in various genetic backgrounds and interaction with different external factors. Finally, we discuss recent publications revealing the association of CETP single nucleotide polymorphisms (SNPs) with the risk of cardiovascular and metabolic diseases, lifestyle factors, diet and therapeutic interventions. While CETP SNPs can be used as effective diagnostic markers, diet, lifestyle, gender and ethnic specificity should also be considered for effective treatment.

Keywords: CETP, lipid transfers, atherosclerosis, lipoproteins, cardiovascular diseases, metabolic syndrome, diabetes mellitus.

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