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Review Article

表面功能化脂质纳米颗粒促进治疗效果:动态给药系统的洞察观点

卷 25, 期 4, 2024

发表于: 22 February, 2024

页: [278 - 300] 页: 23

弟呕挨: 10.2174/0113894501285598240216065627

价格: $65

摘要

与传统方法相比，纳米颗粒(NPs)促进了一种无危险、无毒、无相互作用和生物相容性的系统，使它们在改善药物递送到靶细胞方面具有令人难以置信的前景。当涉及到完成特定的治疗剂，如药物，肽，核苷酸等，脂质纳米颗粒系统已经出现，甚至更强大。他们声称在绕过生理和细胞屏障，逃避溶酶体捕获和质子海绵效应，优化生物利用度和顺应性，降低剂量和提高治疗效果方面具有令人印象深刻的能力。然而，在细胞水平上缺乏选择性阻碍了其充分发挥其潜力的能力。脂质NPs的表面功能化可能有助于它们适应特定病理条件的基本生物学需求。多种配体，包括肽、酶、聚合物、糖、抗体等，可以功能化到脂质NPs的表面，以实现细胞选择性，避免生物活性挑战。这篇综述提供了一个全面的概述功能化脂基NPs系统突出的目标选择性。重点放在加强脂质纳米载体的治疗性能的策略上，使用各种配体以及相关的商业配方实例。

关键词: 表面功能化，脂质纳米颗粒，配体，靶向递送，治疗学，聚乙二醇化。

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