Title:Recent Advances in Biomedical Applications of Mannans and Xylans
Volume: 25
Issue: 4
Author(s): Shriya Teli, Kajal Deshmukh, Tabassum Khan and Vasanti Suvarna*
Affiliation:
- Department of Pharmaceutical Analysis & Quality Assurance, SVKM’s Dr.
Bhanuben Nanavati College of Pharmacy, Mumbai 400056, Maharashtra, India
Keywords:
Mannans, xylans, functionalization, biomedical applications, flavonoids, alkaloids.
Abstract: Plant-based phytochemicals, including flavonoids, alkaloids, tannins, saponins, and
other metabolites, have attracted considerable attention due to their central role in synthesizing
nanomaterials with various biomedical applications. Hemicelluloses are the second most abundant
among naturally occurring heteropolymers, accounting for one-third of all plant constituents. In
particular, xylans, mannans, and arabinoxylans are structured polysaccharides derived from hemicellulose.
Mannans and xylans are characterized by their linear configuration of β-1,4-linked mannose
and xylose units, respectively. At the same time, arabinoxylan is a copolymer of arabinose
and xylose found predominantly in secondary cell walls of seeds, dicotyledons, grasses, and cereal
tissues. Their widespread use in tissue engineering, drug delivery, and gene delivery is based on
their properties, such as cell adhesiveness, cost-effectiveness, high biocompatibility, biodegradability,
and low immunogenicity. Moreover, it can be easily functionalized, which expands their potential
applications and provides them with structural diversity. This review comprehensively addresses
recent advances in the field of biomedical applications. It explores the potential prospects for
exploiting the capabilities of mannans and xylans in drug delivery, gene delivery, and tissue engineering.
