Title:The Protective Effects of Curcumin against Renal Toxicity
Volume: 31
Issue: 35
关键词:
姜黄素,肾保护,炎症,氧化应激,细胞死亡,纤维化。
摘要: Curcumin is a naturally polyphenolic compound used for hepatoprotective,
thrombosuppressive, neuroprotective, cardioprotective, antineoplastic, antiproliferative,
hypoglycemic, and antiarthritic effects. Kidney disease is a major public health problem
associated with severe clinical complications worldwide. The protective effects of curcumin
against nephrotoxicity have been evaluated in several experimental models. In this
review, we discussed how curcumin exerts its protective effect against renal toxicity and
also illustrated the mechanisms of action such as anti-inflammatory, antioxidant, regulating
cell death, and anti-fibrotic. This provides new perspectives and directions for the
clinical guidance and molecular mechanisms for the treatment of renal diseases by curcumin.