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Review Article

The Protective Effects of Curcumin against Renal Toxicity

Author(s): Jianan Zhai, Zhengguo Chen, Qi Zhu, Zhifang Guo, Ningning Wang, Cong Zhang, Haoyuan Deng, Shaopeng Wang* and Guang Yang*

Volume 31, Issue 35, 2024

Published on: 16 February, 2024

Page: [5661 - 5669] Pages: 9

DOI: 10.2174/0109298673271161231121061148

Price: $65

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Abstract

Curcumin is a naturally polyphenolic compound used for hepatoprotective, thrombosuppressive, neuroprotective, cardioprotective, antineoplastic, antiproliferative, hypoglycemic, and antiarthritic effects. Kidney disease is a major public health problem associated with severe clinical complications worldwide. The protective effects of curcumin against nephrotoxicity have been evaluated in several experimental models. In this review, we discussed how curcumin exerts its protective effect against renal toxicity and also illustrated the mechanisms of action such as anti-inflammatory, antioxidant, regulating cell death, and anti-fibrotic. This provides new perspectives and directions for the clinical guidance and molecular mechanisms for the treatment of renal diseases by curcumin.

Keywords: Curcumin, renoprotective, inflammation, oxidative stress, cell death, fibrosis.

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