The Protective Effects of Curcumin against Renal Toxicity

Title:The Protective Effects of Curcumin against Renal Toxicity

Volume: 31

Author(s): Jianan Zhai, Zhengguo Chen, Qi Zhu, Zhifang Guo, Ningning Wang, Cong Zhang, Haoyuan Deng, Shaopeng Wang*Guang Yang*

Affiliation:

• Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian116011, China

• Department of Food Nutrition and Safety, Dalian Medical University, No. 9W. Lushun South Road, Dalian 116044, China

Keywords: Curcumin; Renoprotective; Inflammation; Oxidantive stress; Cell death; Fibrosis.

Abstract: Curcumin is a naturally polyphenolic compound used for hepatoprotective, thrombosuppressive, neuroprotective, cardioprotective, antineoplastic, antiproliferative, hypoglycemic, and antiarthritic effects. Kidney disease is a major public health problem associated with severe clinical complications worldwide. The protective effects of curcumin against nephrotoxicity have been evaluated in several experimental models. In this review, we discussed how curcumin exerts its protective effect against renal toxicity and also illustrated the mechanisms of action such as anti-inflammatory, antioxidant, regulating cell death, and anti-fibrotic. This provides new perspectives and directions for the clinical guidance and molecular mechanisms for the treatment of renal diseases by curcumin.

Cite this article as:

Zhai Jianan, Chen Zhengguo, Zhu Qi, Guo Zhifang, Wang Ningning, Zhang Cong, Deng Haoyuan, Wang Shaopeng*, Yang Guang*, The Protective Effects of Curcumin against Renal Toxicity, Current Medicinal Chemistry 2024; 31 () . https://dx.doi.org/10.2174/0109298673271161231121061148