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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Meta-Analysis

Anticancer Potential of ACEIs/ARBs Administration in Colorectal Cancer

Author(s): Xin Wang and Haiyun Jing*

Volume 31, Issue 30, 2024

Published on: 16 February, 2024

Page: [4867 - 4879] Pages: 13

DOI: 10.2174/0109298673249782231226101119

Price: $65

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Abstract

Background: Colorectal cancer (CC) is the fourth most common type of cancer that causes illness and death. Medicines like ACE inhibitors and ARBs, usually used for heart problems, have shown they might help with the growth and development of CC.

Introduction: An analysis of ACE inhibitors and colon cancer is conducted in this comprehensive review. The main goal is to see how ACEIs/ARBs affect the chances of getting cancer and dying in patients with CC.

Methods: A systematic literature search was conducted to identify relevant studies. Inclusion criteria encompassed studies that evaluated the use of ACEIs/ARBs in patients with CC and reported outcomes related to new cancer incidence and mortality. Data from selected studies were extracted and analyzed using appropriate statistical methods.

Results: The study showed that fewer cancer cases occurred in patients who took ACEIs/ARBs compared to those who did not (RR 0.962, 95% CI 0.934-0.991, p = 0.010). Furthermore, patients with CC who utilized ACEIs/ARBs exhibited a decreased mortality rate compared to non-users (HR 0.833, 95% CI 0.640-1.085, p = 0.175).

Conclusion: This review suggests that using ACEIs/ARBs medicine could help people with CC live longer and lower their chances of dying. These results highlight the potential benefits of utilizing ACE inhibitors in the management of CC, warranting further investigation and consideration in clinical practice.

Keywords: ACE inhibitors, colon cancer, mortality, radiotherapy, ACEIs/ARBs therapy, statistical methods.

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