Title:Natural Products in Liver Fibrosis Management: A Five-year Review
Volume: 31
Issue: 31
Author(s): Tao Wang*, Zhuo Lu, Gui-Feng Sun, Kai-Yi He, Zhi-Ping Chen, Xin-Hui Qu and Xiao-Jian Han*
Affiliation:
- Institute of Geriatrics, Jiangxi Provincial People’s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, P.R. China
- Institute of Geriatrics, Jiangxi Provincial People’s Hospital, the First Affiliated Hospital of Nanchang Medical
College, Nanchang, Jiangxi, 330006, P.R. China
- The Second Department of Neurology, Jiangxi Provincial People’s
Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, P.R.
China
Keywords:
Liver fibrosis, hepatic stellate cell, etiology, antifibrosis, molecular mechanism, natural product, immune cells.
Abstract: Liver fibrosis, characterized by the overproduction of extracellular matrix proteins
within liver tissue, poses a rising global health concern. However, no approved antifibrotic
drugs are currently available, highlighting the critical need for understanding the
molecular mechanisms of liver fibrosis. This knowledge could not only aid in developing
therapies but also enable early intervention, enhance disease prediction, and improve
our understanding of the interaction between various underlying conditions and the liver.
Notably, natural products used in traditional medicine systems worldwide and demonstrating
diverse biochemical and pharmacological activities are increasingly recognized
for their potential in treating liver fibrosis. This review aims to comprehensively understand
liver fibrosis, emphasizing the molecular mechanisms and advancements in exploring
natural products' antifibrotic potential over the past five years. It also acknowledges
the challenges in their development and seeks to underscore their potency in enhancing
patient prognosis and reducing the global burden of liver disease.