Title:Enlarged Perivascular Space in the Basal Ganglia is Associated with Cerebral
Venous Reflux in Patients with Recent Small Subcortical Infarction
Volume: 21
Issue: 2
Author(s): Zhengrong Wu, Ke Zhang, Ce Zong, Hongbing Liu, Yanhong Wang, Yuming Xu and Yuan Gao*
Affiliation:
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Keywords:
Recent small subcortical infarction, cerebral venous reflux, perivascular space, basal ganglia, cerebral small vessel disease, lenticulostriate artery territory.
Abstract:
Background: Research has linked enlarged perivascular spaces (EPVS) to cerebral
venous reflux (CVR) in patients with hypertensive intracerebral hemorrhage, but it is unclear
whether this association exists in recent small subcortical infarct (RSSI) patients.
Objective: This study aimed to investigate the correlation between EPVS and CVR in patients
with RSSI.
Method: This study included 297 patients, selected from patients with RSSI in the lenticulostriate
artery admitted to the Department of Neurology of the First Affiliated Hospital of Zhengzhou
University. CVR was assessed by time-of-flight magnetic resonance angiography (TOF-MRA).
The relationship between EPVS and CVR was studied using multiple logistic regression analysis.
Results: This study included patients with an average age of 59.84±12.27 years, including 201
males (67.7%). CVR was observed in 40 (13.5%) patients. Compared to the group without CVR,
the proportions of male patients and patients with a history of smoking and drinking were higher
in the CVR group. The proportions of high-grade EPVS in the centrum semiovale region [23
cases (57.5%) vs. 108 cases (42.0%), p =0.067] and the basal ganglia region [30 cases (75.0%)
vs. 133 cases (51.8%), p =0.006] were higher in the CVR group. After multiple logistic regression
analysis, high-grade EPVS in the basal ganglia region was still associated with CVR (OR,
2.68; 95% CI, 1.22-5.87;p=0.014).
Conclusion: In the population with RSSI, EPVS in basal ganglia is significantly associated with
CVR, suggesting a close relationship between venous dysfunction and the formation of EPVS.
