Title:Therapeutic Potential of Iron Chelators in Viral Diseases: A
Systematic Review
Volume: 31
Issue: 27
关键词:
铁螯合剂,病毒性疾病,治疗潜力大,安全性好,范围广,作用机制好。
摘要:
Background: Iron chelators (ICs) have recently emerged as one of the new
methods of treatment for viral infections. This study aimed to evaluate the efficiency
and safety of natural ICs compared to synthetic ICs. Natural and synthetic ICs are the
most common therapeutic agents tested for the treatment of viral infections. When evaluated
against synthetic ICs, natural ICs are probably favored owing to their lower toxicity
and safer properties. The main objective of the present systematic review was to assess
the current evidence on the role of pharmacological mechanisms in the treatment of viral
infections.
Methods: This study was designed as a systematic review in which search strategies
were focused on two electronic databases, PubMed, and Scopus, between 2017 and
2021. A search filter with two subjects, “iron chelators” and “viral infection”, was employed.
Results: According to the results, both natural and synthetic chelators had a considerable
impact on the treatment of viral infections
via various mechanisms, with natural
ICs being the most extensively used.
Conclusion: Natural and synthetic ICs exert their effects through different pharmacological
mechanisms. Among these compounds, natural chelators are more widely used due
to their safety, efficacy, and a wider range of applications.