Title:Organelle Targeted Drug Delivery: Key Challenges, Recent Advancements
and Therapeutic Implications
Volume: 24
Issue: 13
Author(s): Dilpreet Singh*
Affiliation:
- Department of Pharmaceutics, University Institute of Pharmaceutical Sciences, Chandigarh University, Gharuan, Mohali, 140413, India
Keywords:
Organelle, drug delivery, therapeutics, targeting, mitochondria, nanocarrier.
Abstract: Organelle-specific targeted drug delivery has emerged as a promising approach in the
field of drug delivery and therapeutics. This innovative strategy involves the precise delivery of
therapeutic agents to specific organelles within cells, such as the nucleus, mitochondria, endoplasmic
reticulum, or lysosomes, with the aim of enhancing drug efficacy while minimizing offtarget
effects. Despite its tremendous potential, organelle-specific drug delivery faces several
key challenges. One major challenge is the development of delivery systems that can accurately
navigate the complex intracellular environment and deliver drugs exclusively to the desired organelles.
Achieving this level of precision demands advanced nanotechnology and biomaterials
engineering. Furthermore, ensuring the safety and biocompatibility of these delivery systems is
paramount. Recent advancements in this field include the development of nanocarriers, such as
liposomes, nanoparticles, and dendrimers, designed to target specific organelles through ligandreceptor
interactions or pH-responsive mechanisms. Additionally, advancements in molecular
biology and genetic engineering have enabled the design of genetically encoded organellespecific
drug delivery systems. The therapeutic implications of organelle-specific drug delivery
are vast. This approach has the potential to revolutionize the treatment of diseases with organelle-
specific pathologies, such as neurodegenerative disorders, cancer, and mitochondrial diseases.
By precisely targeting the organelles involved in disease progression, the efficacy of therapies
can be significantly improved while minimizing collateral damage to healthy tissues.