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Current Pharmaceutical Design

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ISSN (Online): 1873-4286

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Review Article

N-Acylhydrazone Pharmacophore's Analgesic and Anti-inflammatory Profile: Recent Advancements during the Past Ten Years

Author(s): Asmaa E. Kassab*

Volume 30, Issue 5, 2024

Published on: 31 January, 2024

Page: [333 - 351] Pages: 19

DOI: 10.2174/0113816128282470240117072322

Price: $65

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Abstract

Due to its important biological and pharmacological properties, in the field of medicinal chemistry and drug discovery, the N-acylhydrazone motif has shown to be extremely adaptable and promising. This scaffold has become a crucial component in the synthesis of numerous bioactive agents. N-Acylhydrazones are also interesting biological and synthetic tools due to their easy and straightforward synthesis. The current review provides a summary of the analgesic and anti-inflammatory activities of N-acylhydrazone derivatives over the past ten years. A brief discussion of structure-activity relationships is also provided which may guide researchers in medicinal chemistry to develop derivatives based on N-acylhydrazone scaffold as potent anti-inflammatory candidates.

Keywords: N-Acylhydrazone, anti-inflammatory, COX-1, COX-2, LOX, analgesic, SARs.

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