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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Long Non-coding RNA DNM3OS: Pathogenic Roles and Molecular Mechanisms in Pathophysiological Processes

Author(s): Shuwen Wang, Yaqi Hu, Rui Wang, Yifan Zhang, Qi Yuan and Chengfu Yuan*

Volume 31, Issue 29, 2024

Published on: 31 January, 2024

Page: [4687 - 4702] Pages: 16

DOI: 10.2174/0109298673280484240101070607

Price: $65

Open Access Journals Promotions 2
Abstract

Background: Long non-coding RNA (lncRNA) is a class of single-stranded RNA biomolecules involving over 200 nucleotides and does not encode proteins. Research on lncRNA has become a hot spot for the past few years. DNM3OS (Dynamin 3 Opposite Strand), which has been clearly identified as a regulatory lncRNA, exerts an integral role in the pathophysiology of multiple human diseases.

Objective: The current review study summarizes the pathogenic mechanism of DNM3OS in various pathophysiological processes, aiming to reveal its important value as a therapeutic drug target for related human diseases and provide a new way for targeted therapy.

Methods: Through systematic retrieval and in-depth study of relevant articles in PubMed, this article analyzes and summarizes the pathogenic roles and molecular mechanisms in pathophysiological processes of long non-coding RNA DNM3OS.

Results: DNM3OS exerts an important regulatory role in the occurrence and development of bone diseases, neoplastic diseases, fibrotic diseases, inflammatory diseases, and many other diseases.

Conclusion: DNM3OS is a potential new biomarker and therapeutic target for the treatment of a series of diseases, consisting of bone diseases, neoplastic diseases, fibrotic diseases, and inflammatory diseases.

Keywords: LncRNA, DNM3OS, skeletal development, neoplastic diseases, inflammation, fibrotic, diseases.

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