Research Article

肥厚性心肌病中循环miR-21和-29的表达及其与心肌纤维化的关系

卷 31, 期 25, 2024

发表于: 30 January, 2024

页: [3987 - 3996] 页: 10

弟呕挨: 10.2174/0109298673286017240103073130

摘要

背景:肥厚性心肌病(HCM)以心肌肥大、纤维化和肌体紊乱为特征。 目的:评估HCM患者循环miR-21和-29的表达水平及其与临床特征和心肌纤维化的关系。 方法:在本病例对照研究中,纳入27例HCM患者、13例高血压心肌病患者和10例对照患者。通过6分钟步行测试评估患者的功能能力。超声心动图测量左心室收缩和舒张功能。心脏磁共振晚期钆增强(LGE) -通过半定量评估-用于评估HCM患者心肌纤维化程度。通过定量逆转录聚合酶链反应方法检测所有患者外周血样本中miR-21和-29的表达。 结果:与对照组相比,高血压和HCM患者的循环miR-21水平更高(p<0.001),而miR-29的表达在三个研究组之间没有差异。在HCM和LGE检测的17个心肌节段中有4个以上心肌纤维化的患者中,deltaCT miR-21值低于3个或更少心肌节段的LGE患者(2.71±1.06 deltaCT vs. 3.50±0.55 deltaCT, p<0.04),表明循环miR-21在更广泛的心肌纤维化患者中表达更高。 结论:MiR-21在HCM和高血压心肌病患者中过表达。重要的是,在HCM患者中,更广泛的心肌纤维化与更高水平的miR-21相关。

关键词: 肥厚性心肌病,miR-21, miR-29,心肌纤维化,心力衰竭,超声心动图。

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