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Review Article

治疗性多肽的免疫原性评价

卷 31, 期 26, 2024

发表于: 24 January, 2024

页: [4100 - 4110] 页: 11

弟呕挨: 10.2174/0109298673264899231206093930

价格: $65

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摘要

在过去的几十年里，治疗肽在临床实践中的应用取得了显著进展。然而，免疫原性仍然是治疗性肽开发中不可避免的关键问题。MHCⅱ类抗原肽的预测是评价治疗性肽免疫原性的重要方法。近年来，随着算法和数据库的不断升级，预测精度得到了显著提高。这使得计算机评价成为治疗性多肽开发中免疫原性评价的重要组成部分。本文综述了MHC II类分子抗原肽肽-MHC-II结合预测方法的研究进展，并对最先进的预测方法进行了系统的解释，旨在加深我们对这一需要特别关注的领域的理解。

关键词: 治疗性多肽、免疫原性、抗药物抗体、主要组织相容性复合体、机器学习、深度学习、人类白细胞抗原。

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