Title:Towards Antiviral Potential of Biomolecules Derived from Adhatod avasica
as Competent Natural Molecules to Treat COVID-19 Virus Variant
Volume: 21
Issue: 5
Author(s): Mohammad Asif*, Mohd Yusuf, Mazen Almehmadi, Ahad Amer Alsaiari, Mamdouh Allahyani, Abdulelah Aljuaid and Abdulaziz Alsharif
Affiliation:
- Department of Pharmaceutical Chemistry, Era College of Pharmacy, Era University, Lucknow, 226003, Uttar Pradesh,
India
Keywords:
Adhatoda vasica, phytoconstituents, Coronavirus (COVID-19), in-silico study, traditional medicines, viral diseases.
Abstract: Adhatoda vasica (L.) (Acanthaceae) has essential therapeutic roles and is widely used in
the indigenous medicine system or Ayurvedic system of medicine. The important goals of the present
study are to report the in-silico anti-corona (COVID-19) activity of different phytochemicals
present in A. vasica. This study will help to find specific bioactive compounds, and their use as anti-
COVID-19 action for human welfare. A. vasica has chemical phytoconstituents with diverse pharmacological
activities. These phytoconstituents have been found active against many diseases such as
antibacterial, antitubercular, antivirus, antitussive, hepatoprotective, antiinflammatory, antiulcer, antiurolithiatic,
abortifacient, radio modulator, cardio-protection, antidiabetic, antioxidant, anticancer,
thrombolytic, antimutagenic, etc. Researchers have been lured to the use of natural and sustainable
products with substantial therapeutic potential in the current climate of environmental preservation
and safe use. These materials permit biological activity, safety, and compatibility with the environment.
Using the SARS-CoV-2 spike receptor (6M0J), we evaluated Adhatoda vasica biomolecules
for the Covid-19 variant (RBD- COV-2-S). This study is very encouraging and indicates that herbs
should be studied more extensively for their therapeutic benefits.
