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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

A Green and Convenient Approach for the Synthesis of Indole-acrylonitrile and Indole-coumarin Hybrids in Aqueous Media

Author(s): Adeleh Moshtaghi Zonouz* and Davoud Moghani

Volume 21, Issue 5, 2024

Published on: 22 January, 2024

Page: [448 - 455] Pages: 8

DOI: 10.2174/0115701786275818231117053307

Price: $65

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Abstract

Indole–acrylonitrile hybrids were synthesized via a catalyst-free reaction of aromatic aldehydes and 3-(cyanoacetyl)indole in aqueous media. Also, indole-coumarin hybrids were synthesized via a domino reaction of salicylaldehyde derivatives and 3-(cyanoacetyl)indole in the presence of ammonium acetate in aqueous media. The advantages of the present protocol are high yields, short reaction times, mild reaction conditions, operational simplicity, and environmentally benign, and also there is no need to purification of products.

Keywords: Indole–acrylonitrile hybrids, indole-coumarin hybrids, aqueous media, domino reaction, anti-inflammatory, organic solvents.

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