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Review Article

细胞外囊泡参与肿瘤转移不同阶段及靶向策略的研究进展

卷 31, 期 28, 2024

发表于: 19 January, 2024

页: [4495 - 4509] 页: 15

弟呕挨: 10.2174/0109298673273299231121044055

价格: $65

Open Access Journals Promotions 2
摘要

肿瘤转移是肿瘤发生中最致命的事件。尽管进行了广泛的研究，但在早期转移检测和靶向策略方面仍存在未解决的挑战。细胞外囊泡(EVs)及其对肿瘤发生相关事件的影响是当前研究的重点。ev代表了大量的生物标志物和信息，它们被认为是肿瘤进展和肿瘤预后和监测的关键决定因素。ev是肿瘤细胞与其附近基质之间细胞间通讯的关键介质之一。它们参与了从侵袭到转移前生态位(pmn)的形成，以及肿瘤细胞在目标器官的最终生长和定植的不同步骤。ev及其运载物的膜组分可用于肿瘤转移的识别，其靶向治疗是一种很有前途的癌症治疗策略。在这篇综述中，我们旨在讨论目前对肿瘤中基于EV的转移倾向的理解，提供EV参与不同转移步骤的最新信息，并提出一些阻止这种破坏性疾病的策略。

关键词: 细胞外囊泡(EV)、外泌体、转移、肿瘤微环境(TME)、癌症相关成纤维细胞(CAF)、转化生长因子(TGF)、转移前生态位(PMN)。

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