Title:A Correlation Study to Comprehend the SAR-CoV-2 Viral Load, Antiviral
Antibody Titer, and Severity of COVID-19 Symptoms Post-infection
Amongst the Vaccinated Population in Kamrup District of As sam,
Northeast India
Volume: 24
Issue: 12
Author(s): Aparup Patra, Asis Bala, Mojibur R. Khan and Ashis K. Mukherjee*
Affiliation:
- Institute of Advanced Studies in Science and Technology, Vigyan Path Garchuk, Paschim Boragaon, Guwahati-781035,
Assam, India
Keywords:
SARS-CoV-2, IgG against SARS-CoV-2 vaccination, COVID-19, cycle threshold value, serum immunoglobulin, vaccinated population.
Abstract:
Background: As per the recommendation of the United States Food and Drug
Administration, more research is needed to determine the antibody titer against COVID-19
vaccination.
Objective: The study aimed to understand the relationship between the antibody titer to the demographics,
infection severity, and cycle threshold (CT) values of confirmed COVID-19 patients.
Methods: Initially, we obtained consent from 185 populations and included sixty RT-PCRpositive
COVID-19 patients from Kamrup District in the Northeast State of Assam, India. The
vaccination status was recorded and tested for the level of serum immunoglobulin (IgG). The CT
values, gender, and clinical symptoms-based scoring (CSBS) correlated with their IgG value.
Results: Around 48% of participants gained an antibody titer more than the threshold value and
showed CT values between 18-25. Moreover, the maximum distributed score above the average
was found between the CT values 18-25.
Conclusion: The IgG titer value differs significantly amongst the vaccinated population, which
may depend upon their genetic and demographic variability.